Mitochondrial 12S ribosomal RNA A1555G mutation associated with cardiomyopathy and hearing loss following high-dose chemotherapy and repeated aminoglycoside exposure.
J Pediatr
; 164(2): 413-5, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24252789
ABSTRACT
A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation. She had received gentamicin during episodes of febrile neutropenia. Testing for the A1555G mutation is recommended in patients frequently treated with aminoglycosides.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN Ribosómico
/
Aminoglicósidos
/
Pérdida Auditiva Sensorineural
/
Mutación
/
Cardiomiopatías
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Infant
Idioma:
En
Revista:
J Pediatr
Año:
2014
Tipo del documento:
Article
País de afiliación:
Dinamarca