Aluminum-related bone disease. Correlation between symptoms, osteoid volume, and aluminum staining.
Am J Clin Pathol
; 86(2): 168-74, 1986 Aug.
Article
en En
| MEDLINE
| ID: mdl-2426938
ABSTRACT
In order to correlate symptoms, osteoid volume, and aluminum deposition in bone, 46 methacrylate-embedded biopsy specimens from 26 hemodialysis patients were examined. Osteoid volume was measured using computer-assisted morphometric analysis, and aluminum was detected using the Aluminon stain. Positive staining for aluminum was present in biopsies from 21 patients. Osteoid volume did not correlate with duration of dialysis therapy or ingestion of aluminum hydroxide but displayed a logarithmic relationship with dialysate aluminum exposure. Patients with bone pain at the time of biopsy had a greater degree of hyperosteoidosis than asymptomatic subjects. Osteoid volume in patients with fractures and positive aluminum staining decreased on withdrawal from aluminum-rich dialysate. The Aluminon staining technic is a convenient method of confirming aluminum overload.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Huesos
/
Enfermedades Óseas
/
Diálisis Renal
/
Aluminio
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Clin Pathol
Año:
1986
Tipo del documento:
Article