Almost a tragedy: severe methotrexate toxicity in a hemodialysis patient treated for ectopic pregnancy.
Eur J Clin Pharmacol
; 70(3): 261-3, 2014 Mar.
Article
en En
| MEDLINE
| ID: mdl-24276413
ABSTRACT
BACKGROUND:
Methotrexate (MTX), an antimetabolite of folic acid, is the drug of choice for the nonsurgical management of ectopic pregnancy. MTX-related toxicity may include leukopenia, thrombocytopenia, pancytopenia, nausea, vomiting, stomatitis, mucositis, and liver and lung toxicity, depending primarily on the dosage of the drug and patients' renal function. Currently, the use of MTX in hemodialysis patients, even at a low dosage, is controversial, and no clear-cut guidelines are available. CASE REPORT We report here a rare case of a life-threatening complication characterized by severe pancytopenia and skin and mucosal injury, which developed in a young patient on hemodialysis after oral treatment with MTX for ectopic pregnancy.CONCLUSION:
We conclude that even low-dose MTX administration is not to be used in patients with renal insufficiency, and when no other therapeutic options are available we suggest taking several clinical measures to prevent or treat myelosuppression.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Embarazo Ectópico
/
Metotrexato
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Guideline
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Eur J Clin Pharmacol
Año:
2014
Tipo del documento:
Article