Antiproliferative evaluation of N-sulfonyl-2-alkyl-six membered azacycles. A QSAR study.
Med Chem
; 10(6): 571-9, 2014.
Article
en En
| MEDLINE
| ID: mdl-24283219
ABSTRACT
A series of functionalized N-sulfonyl-piperidines and N-sulfonyl-tetrahydropyridines were evaluated for their antiproliferative activity against the representative panel of human solid tumor cells A2780 (ovarian), SW1573 (non-small cell lung) and WiDr (colon). The SAR study showed for WiDr cells a correlation between the biological activity and the length of the N-sulfonyl group, the nature of the substituents and the type of alkyl side chain. Further QSAR studies indicate that the size and nature of the N-sulfonyl group, the atomic polarizability (MP) and the partition coefficient are the most important descriptors for the activity. The major contribution is the size (F05C-S) of the N-sulfonyl group.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sulfonas
/
Compuestos Aza
/
Proliferación Celular
/
Compuestos Heterocíclicos
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Med Chem
Asunto de la revista:
QUIMICA
Año:
2014
Tipo del documento:
Article