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A small-molecule inducer of PDX1 expression identified by high-throughput screening.
Yuan, Yuan; Hartland, Kate; Boskovic, Zarko; Wang, Yikai; Walpita, Deepika; Lysy, Philippe A; Zhong, Cheng; Young, Damian W; Kim, Young-Kwon; Tolliday, Nicola J; Sokal, Etienne M; Schreiber, Stuart L; Wagner, Bridget K.
Afiliación
  • Yuan Y; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Hartland K; Chemical Biology Platform, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Boskovic Z; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Wang Y; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Walpita D; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Lysy PA; Laboratory of Pediatric Hepatology and Cell Therapy, Catholic University of Leuven, Brussels 1200, Belgium.
  • Zhong C; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Young DW; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Kim YK; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Tolliday NJ; Chemical Biology Platform, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Sokal EM; Laboratory of Pediatric Hepatology and Cell Therapy, Catholic University of Leuven, Brussels 1200, Belgium.
  • Schreiber SL; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Wagner BK; Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: bwagner@broadinstitute.org.
Chem Biol ; 20(12): 1513-22, 2013 Dec 19.
Article en En | MEDLINE | ID: mdl-24290880
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Transactivadores / Proteínas de Homeodominio / Carcinoma Ductal Pancreático / Carcinoma Ductal / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Chem Biol Asunto de la revista: BIOLOGIA / BIOQUIMICA / QUIMICA Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Transactivadores / Proteínas de Homeodominio / Carcinoma Ductal Pancreático / Carcinoma Ductal / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Chem Biol Asunto de la revista: BIOLOGIA / BIOQUIMICA / QUIMICA Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos