(+)-Catechin attenuates activation of hepatic stellate cells.
Cell Biol Int
; 38(4): 526-30, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24353036
ABSTRACT
(+)-Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor γ mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Catequina
/
Células Estrelladas Hepáticas
Límite:
Animals
Idioma:
En
Revista:
Cell Biol Int
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil