Expression and prognostic significance of CIP2A in cutaneous malignant melanoma.
Biomarkers
; 19(1): 70-6, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24369732
ABSTRACT
OBJECTIVE:
We investigated the expression and clinical significance of Cancerous inhibitor of protein phosphatase 2A (CIP2A) in Cutaneous malignant melanoma (CMM).METHODS:
CIP2A expression was analyzed by immunohistochemistry and western blot. We tested the invasion and migration capability of A375 cells with Matrigel invasion assay, Scratch migration assay and Matrigel migration assay after down-regulating CIP2A expression using siRNA.RESULTS:
CIP2A immunostaining level was correlated with Breslow thickness, Clark's Level and lymphovascular invasion. High-CIP2A expression implied poor survival for patients. Downregulation of CIP2A attenuated metastasis of CMM cells.CONCLUSIONS:
CIP2A may serve as a novel marker to predict the prognosis for CMM patients.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Autoantígenos
/
Biomarcadores de Tumor
/
Melanoma
/
Proteínas de la Membrana
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomarkers
Asunto de la revista:
BIOQUIMICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
China