Sequence-dependence of the conformational changes induced by the 5-methyl cytosine in synthetic RNA oligomers.
FEBS Lett
; 219(2): 464-8, 1987 Jul 27.
Article
en En
| MEDLINE
| ID: mdl-2440719
ABSTRACT
The RNA hexamer containing a 5-methyl cytosine (m5C) r(CGUAm5CG) was studied by 1H and 31P NMR at 500 MHz and 121 MHz, respectively. In contrast to r(CGm5CGCG) which exhibits an atypic duplex structure [(1987) J. Am. Chem. Soc. 109, 2539-2541], r(CGUAm5CG) adopts a classical A-type conformation. This result demonstrates that the influence of the m5C on the conformation of RNA hexamers is sequence-dependent.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oligorribonucleótidos
/
ARN
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Citosina
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Conformación de Ácido Nucleico
Idioma:
En
Revista:
FEBS Lett
Año:
1987
Tipo del documento:
Article