Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents.

Baretella, Oliver; Chung, Sookja K; Barton, Matthias; Xu, Aimin; Vanhoutte, Paul M

Baretella, Oliver; Chung, Sookja K; Barton, Matthias; Xu, Aimin; Vanhoutte, Paul M.

Afiliación

Baretella O; Department of Pharmacology & Pharmacy, and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong,China.
Chung SK; Department of Anatomy, The University of Hong Kong, Hong Kong,China; Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, Hong Kong,China.
Barton M; Molecular Internal Medicine, University of Zürich, 8057 Zürich, Switzerland.
Xu A; Department of Pharmacology & Pharmacy, and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong,China; Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, Hong Kong,China; Department of Medicine, The University of Hon
Vanhoutte PM; Department of Pharmacology & Pharmacy, and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong,China; Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, Hong Kong,China. Electronic address: vanhoutt@hku.hk.

Life Sci ; 118(2): 206-12, 2014 Nov 24.

Article en En | MEDLINE | ID: mdl-24412387

Asunto(s)

Endotelina-1/metabolismo; Obesidad/metabolismo; Obesidad/fisiopatología; Arteria Renal/fisiopatología; Vasoconstrictores/farmacología; Animales; Presión Sanguínea/efectos de los fármacos; Endotelio Vascular/efectos de los fármacos; Endotelio Vascular/metabolismo; Endotelio Vascular/fisiopatología; Heterocigoto; Pruebas de Función Renal; Masculino; Ratones Endogámicos C57BL; Receptores de Tromboxanos/agonistas; Receptores de Tromboxanos/metabolismo; Arteria Renal/efectos de los fármacos; Serotonina/farmacología; Delgadez/metabolismo; Vasoconstricción/efectos de los fármacos

Palabras clave

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid (U46619, PubChem CID: 5311493); ET-1; ET-1 (PubChem CID: 16212950); Endothelium; Serotonin; Serotonin hydrochloride (PubChem CID: 160436); TP receptor; U46619; l-NAME hydrochloride (PubChem CID: 135193)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arteria Renal / Vasoconstrictores / Endotelina-1 / Obesidad Límite: Animals Idioma: En Revista: Life Sci Año: 2014 Tipo del documento: Article País de afiliación: China

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