Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.

Xu, Shu; Hermanson, Daniel J; Banerjee, Surajit; Ghebreselasie, Kebreab; Clayton, Gina M; Garavito, R Michael; Marnett, Lawrence J

Xu, Shu; Hermanson, Daniel J; Banerjee, Surajit; Ghebreselasie, Kebreab; Clayton, Gina M; Garavito, R Michael; Marnett, Lawrence J.

Afiliación

Xu S; A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Hermanson DJ; A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Banerjee S; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853; Northeastern Collaborative Access Team, Argonne National Laboratory, Argonne, Illinois 60439.
Ghebreselasie K; A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Clayton GM; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824.
Garavito RM; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824.
Marnett LJ; A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232. Electr

J Biol Chem ; 289(10): 6799-6808, 2014 Mar 07.

Article en En | MEDLINE | ID: mdl-24425867

Asunto(s)

Antiinflamatorios no Esteroideos/metabolismo; Ciclooxigenasa 1/metabolismo; Ciclooxigenasa 2/metabolismo; Inhibidores de la Ciclooxigenasa/metabolismo; Piroxicam/análogos & derivados; Tiazinas/metabolismo; Tiazoles/metabolismo; Sustitución de Aminoácidos; Animales; Antiinflamatorios no Esteroideos/química; Arginina/química; Arginina/genética; Arginina/metabolismo; Sitios de Unión; Dominio Catalítico; Ciclooxigenasa 1/química; Ciclooxigenasa 1/genética; Ciclooxigenasa 2/química; Ciclooxigenasa 2/genética; Inhibidores de la Ciclooxigenasa/química; Enlace de Hidrógeno; Leucina/química; Leucina/genética; Leucina/metabolismo; Meloxicam; Ratones; Mutación; Piroxicam/química; Piroxicam/metabolismo; Estructura Secundaria de Proteína; Serina/química; Serina/genética; Serina/metabolismo; Tiazinas/química; Tiazoles/química; Tirosina/química; Tirosina/genética; Tirosina/metabolismo; Agua

Palabras clave

Cyclooxygenase (COX) Pathway; Drug Action; Enzyme Structure; Protein Drug Interactions; X-ray Crystallography

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tiazinas / Tiazoles / Piroxicam / Antiinflamatorios no Esteroideos / Inhibidores de la Ciclooxigenasa / Ciclooxigenasa 1 / Ciclooxigenasa 2 Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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