Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
Circ Res
; 114(3): 538-48, 2014 Jan 31.
Article
en En
| MEDLINE
| ID: mdl-24481844
ABSTRACT
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of proteins within the inner and the outer nuclear membranes, connects the nuclear lamina to the cytoskeleton. The importance of this complex has been highlighted by the discovery of mutations in genes encoding LINC complex proteins, which cause skeletal or cardiac myopathies. Herein, this review summarizes structure, function, and interactions of major components of the LINC complex, highlights how mutations in these proteins may lead to cardiac disease, and outlines future challenges in the field.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Citoesqueleto
/
Matriz Nuclear
/
Miocitos Cardíacos
/
Plaquinas
/
Cardiopatías
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Circ Res
Año:
2014
Tipo del documento:
Article
País de afiliación:
Canadá