Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.
J Exp Med
; 211(2): 181-8, 2014 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-24493804
ABSTRACT
The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi- and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive role in vivo, through suppression of non-erythroid fate options, demonstrating the ability of a cytokine to systematically bias successive lineage choices in favor of the generation of a specific cell type.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Hematopoyéticas
/
Células Precursoras Eritroides
/
Eritropoyetina
/
Células Madre Multipotentes
/
Eritropoyesis
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido