Oligo(ethylene glycol)-based thermosensitive dendrimers and their tumor accumulation and penetration.
J Am Chem Soc
; 136(8): 3145-55, 2014 Feb 26.
Article
en En
| MEDLINE
| ID: mdl-24506735
ABSTRACT
Dendrimers have several featured advantages over other nanomaterials as drug carriers, such as well-defined structure, specific low-nanometer size, and abundant peripheral derivable groups, etc. However, these advantages have not been fully exploited yet to optimize their biological performance, especially tumor penetration, which is a shortcoming of current nanomaterials. Here we show the syntheses of a new class of oligo(ethylene glycol) (OEG)-based thermosensitive dendrimers up to the fourth generation. Each dendrimer shows monodisperse structure. OEG/poly(ethylene glycol) (PEG) moieties with different precise lengths were introduced to the periphery of the fourth-generation dendrimer followed by an antitumor agent, gemcitabine (GEM). The biodistributions of the GEM-conjugated dendrimers were investigated by micro positron emission tomography and multispectral optoacoustic tomography imaging techniques and compared with that of GEM-conjugated poly(amidoamine) (PAMAM). The GEM-conjugated dendrimer with the longest peripheral PEG segments exhibited the most desirable tumor accumulation and penetration and thus had significantly higher antitumor activity than the GEM-conjugated PAMAM.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polietilenglicoles
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Neoplasias de la Mama
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Portadores de Fármacos
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Desoxicitidina
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Dendrímeros
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Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
J Am Chem Soc
Año:
2014
Tipo del documento:
Article