MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice.

Nezami, Behtash Ghazi; Mwangi, Simon M; Lee, Jai Eun; Jeppsson, Sabrina; Anitha, Mallappa; Yarandi, Shadi S; Farris, Alton B; Srinivasan, Shanthi

Nezami, Behtash Ghazi; Mwangi, Simon M; Lee, Jai Eun; Jeppsson, Sabrina; Anitha, Mallappa; Yarandi, Shadi S; Farris, Alton B; Srinivasan, Shanthi.

Afiliación

Nezami BG; Department of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center, Decatur, Georgia.
Mwangi SM; Department of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center, Decatur, Georgia.
Lee JE; Department of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center, Decatur, Georgia.
Jeppsson S; Department of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center, Decatur, Georgia.
Anitha M; Department of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center, Decatur, Georgia.
Yarandi SS; Department of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center, Decatur, Georgia.
Farris AB; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia.
Srinivasan S; Department of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center, Decatur, Georgia. Electronic address: ssrini2@emory.edu.

Gastroenterology ; 146(2): 473-83.e3, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24507550

Asunto(s)

Dieta Alta en Grasa/efectos adversos; Grasas de la Dieta/efectos adversos; Sistema Nervioso Entérico/patología; Tránsito Gastrointestinal/fisiología; MicroARNs/metabolismo; Neuronas/patología; Palmitatos/efectos adversos; Animales; Apoptosis/fisiología; Biomarcadores/metabolismo; Línea Celular; Colon/inervación; Colon/patología; Colon/fisiopatología; Sistema Nervioso Entérico/fisiopatología; Masculino; Ratones; Ratones Endogámicos C57BL; MicroARNs/administración & dosificación; MicroARNs/antagonistas & inhibidores; Neuronas/fisiología; Proteínas Serina-Treonina Quinasas/metabolismo; Piruvato Deshidrogenasa Quinasa Acetil-Transferidora; Distribución Aleatoria; Estrés Fisiológico

Palabras clave

3-phosphoinositide-dependent protein kinase-1; ChAT; ENS; ER; FFAs; FITC; GI; Gastrointestinal; HFD; Hyperlipidemia; LP-HFD; MicroRNAs; Motility; NADPH diaphorase; Pdk1; RD; SOD; choline acetyltransferase; endoplasmic reticulum; enteric nervous system; fluorescein isothiocyanate; free fatty acids; gastrointestinal; high-fat diet; low-palmitate HFD; mRNA; messenger RNA; miRNAs; microRNAs; nicotinamide adenine dinucleotide phosphate; regular diet; superoxide dismutase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Palmitatos / Tránsito Gastrointestinal / Grasas de la Dieta / Sistema Nervioso Entérico / MicroARNs / Dieta Alta en Grasa / Neuronas Límite: Animals Idioma: En Revista: Gastroenterology Año: 2014 Tipo del documento: Article País de afiliación: Georgia

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