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High fat diet aggravates arsenic induced oxidative stress in rat heart and liver.
Dutta, Mousumi; Ghosh, Debosree; Ghosh, Arnab Kumar; Bose, Gargi; Chattopadhyay, Aindrila; Rudra, Smita; Dey, Monalisa; Bandyopadhyay, Arkita; Pattari, Sanjib K; Mallick, Sanjaya; Bandyopadhyay, Debasish.
Afiliación
  • Dutta M; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India; Department of Physiology, Vidyasagar College, Kolkata 700 006, India.
  • Ghosh D; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
  • Ghosh AK; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
  • Bose G; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
  • Chattopadhyay A; Department of Physiology, Vidyasagar College, Kolkata 700 006, India.
  • Rudra S; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
  • Dey M; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
  • Bandyopadhyay A; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
  • Pattari SK; RN Tagore International Institute of Cardiac Sciences, 124, Mukundapur, E.M. Bypass, Kolkata 700 099, India.
  • Mallick S; Acharya Prafulla Chandra Sikhsha Prangan, University of Calcutta, Salt Lake Campus, JD-2, Sector-III, Salt Lake City, Kolkata 700 098, India.
  • Bandyopadhyay D; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India; Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, University College of S
Food Chem Toxicol ; 66: 262-77, 2014 Apr.
Article en En | MEDLINE | ID: mdl-24508525
ABSTRACT
Arsenic is a well known global groundwater contaminant. Exposure of human body to arsenic causes various hazardous effects via oxidative stress. Nutrition is an important susceptible factor which can affect arsenic toxicity by several plausible mechanisms. Development of modern civilization led to alteration in the lifestyle as well as food habits of the people both in urban and rural areas which led to increased use of junk food containing high level of fat. The present study was aimed at investigating the effect of high fat diet on heart and liver tissues of rats when they were co-treated with arsenic. This study was established by elucidating heart weight to body weight ratio as well as analysis of the various functional markers, oxidative stress biomarkers and also the activity of the antioxidant enzymes. Histological analysis confirmed the biochemical investigations. From this study it can be concluded that high fat diet increased arsenic induced oxidative stress.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arsénico / Estrés Oxidativo / Dieta Alta en Grasa / Corazón / Hígado Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2014 Tipo del documento: Article País de afiliación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arsénico / Estrés Oxidativo / Dieta Alta en Grasa / Corazón / Hígado Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2014 Tipo del documento: Article País de afiliación: India