Copper deficiency impairs growth of infants recovering from malnutrition.
Am J Clin Nutr
; 47(4): 710-4, 1988 Apr.
Article
en En
| MEDLINE
| ID: mdl-2451417
ABSTRACT
To evaluate the effect of copper deficiency on growth in humans we performed a prospective case-control study in 11 infants identified as Cu deficient based on low plasma Cu (less than 70 micrograms/dL [11.0 mumol/L]) and low ceruloplasmin (less than 200 mg/L). Growth was evaluated with anthropometric indices 1 mo before and 1 mo after onset of Cu supplementation of 80 micrograms.kg-1.d-1. Plasma Cu and ceruloplasmin rose significantly after 1 mo of supplementation. Weight-for-age and weight-for-length indices increased significantly after supplementation only in the Cu-deficient group. Daily energy intake was significantly higher in the Cu-deficient group after supplementation than it was in the control group. Daily weight gain after supplementation increased significantly in the Cu-deficient group and the value for daily weight gain after supplementation was significantly higher than that of the control group for the equivalent amount of time. Cu supplementation improves the growth of Cu-deficient infants recovering from malnutrition.
ABSTRACT
PIP To evaluate the effect of copper deficiency on growth in humans a prospective case-control study was performed in Chile on a group of 11 infants identified as Cu deficient based on low plasma Cu (70 mcg/dL (11.0 mcmol/L) and low ceruloplasmin (200 mg/L). Growth was evaluated with anthropometric indices 1 month before and 1 month after onset of Cu supplementation of 80 mcg x 1/kg x 1/d. Plasma Cu and ceruloplasmin rose significantly after 1 month of supplementation. Weight-for-age and weight-for-length indices increased significantly after supplementation only in the Cu-deficient group. Daily energy intake was significantly higher in the Cu-deficient group after supplementation than it was in the control group. Daily weight gain after supplementation increased significantly in the Cu-deficient group and the value for daily weight gain after supplementation was significantly higher than that of the control group for the equivalent amount of time. Cu supplementation improves the growth of Cu-deficient infants recovering from malnutrition.
Palabras clave
Americas; Anthropometry; Biology; Child Development; Chile; Copper; Deficiency Diseases; Developed Countries; Developing Countries; Diseases; Growth; Health; Infant Nutrition; Ingredients And Chemicals; Inorganic Chemicals; Latin America; Malnutrition; Measurement; Metals; Nutrition; Nutrition Disorders; Research Methodology; Research Report; South America; Supplementary Feeding; Treatment
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Discapacidades del Desarrollo
/
Cobre
/
Enfermedades Carenciales
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Am J Clin Nutr
Año:
1988
Tipo del documento:
Article