Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum.
Science
; 240(4857): 1324-6, 1988 Jun 03.
Article
en En
| MEDLINE
| ID: mdl-2453924
ABSTRACT
In a study aimed at developing a vaccine against the asexual blood stages of Plasmodium falciparum, two T cell epitopes were identified within a nonpolymorphic region of gp190 of Plasmodium falciparum merozoites. The two epitopes, which were revealed by deletion analysis, stimulated human T cell clones. Peptides containing sequences of the epitopes stimulated the cloned T cells and peripheral blood mononuclear cells (PBMC) from malaria-infected individuals. Moreover, the T cell clones responded to 11 different Plasmodium falciparum isolates in culture, showing that the epitopes are recognized in native parasites.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Linfocitos T
/
Epítopos
/
Antígenos de Protozoos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1988
Tipo del documento:
Article
País de afiliación:
Alemania