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Pediatric low-grade gliomas: how modern biology reshapes the clinical field.
Bergthold, Guillaume; Bandopadhayay, Pratiti; Bi, Wenya Linda; Ramkissoon, Lori; Stiles, Charles; Segal, Rosalind A; Beroukhim, Rameen; Ligon, Keith L; Grill, Jacques; Kieran, Mark W.
Afiliación
  • Bergthold G; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bandopadhayay P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Boston Children's Hospital, Boston, MA, USA.
  • Bi WL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ramkissoon L; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Stiles C; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Segal RA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
  • Beroukhim R; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ligon KL; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Grill J; Departement de Cancerologie de l'enfant et de l'adolescent, Gustave Roussy and Unité Mixte de Recherche 8203 du Centre National de la Recherche Scientifique, Université Paris-Sud, Villejuif, France.
  • Kieran MW; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: mark_kieran@dfci.harvard.edu.
Biochim Biophys Acta ; 1845(2): 294-307, 2014 Apr.
Article en En | MEDLINE | ID: mdl-24589977
ABSTRACT
Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochim Biophys Acta Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochim Biophys Acta Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos