Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi.
Chin J Nat Med
; 12(2): 121-5, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24636062
ABSTRACT
AIM:
To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi.METHOD:
The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions were evaluated on the inhibition on lipopolysaccharide (LPS)-induced nitric oxide, prostaglandin E2, interleukin-1ß, and interleukin-6 production in RAW 264.7 macrophages.RESULTS:
The 80% MeOH fraction was a better inhibitor of LPS-induced NO, PGE2, IL-1ß, and IL-6 production, and expression of inducible nitric oxide synthase (iNOS) at the protein levels in a concentration-dependent manner.CONCLUSION:
The 80% MeOH fraction of A. henryi root bark has significant anti-inflammatory activity. This provides a pharmacological basis for clinical application for the treatment of inflammation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Eleutherococcus
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Inflamación
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Macrófagos
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Fitoterapia
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Chin J Nat Med
Año:
2014
Tipo del documento:
Article