Your browser doesn't support javascript.
loading
Prognostic impact of genomic instability in colorectal cancer.
Hveem, T S; Merok, M A; Pretorius, M E; Novelli, M; Bævre, M S; Sjo, O H; Clinch, N; Liestøl, K; Svindland, A; Lothe, R A; Nesbakken, A; Danielsen, H E.
Afiliación
  • Hveem TS; 1] Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [3] Department of Informatics, University of Oslo, PO Box 1080 Blindern, 0316 Oslo, Norway.
  • Merok MA; 1] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, PO Box 4953 Nydalen, 0424 Oslo, Norway [3] Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blinde
  • Pretorius ME; 1] Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway.
  • Novelli M; 1] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Department of Pathology, University College Hospital, London WC1E 6JJ, UK.
  • Bævre MS; 1] Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway.
  • Sjo OH; Department of Gastrointestinal Surgery, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway.
  • Clinch N; Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway.
  • Liestøl K; 1] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Department of Informatics, University of Oslo, PO Box 1080 Blindern, 0316 Oslo, Norway.
  • Svindland A; 1] Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway [2] Department of Pathology, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway.
  • Lothe RA; 1] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, PO Box 4953 Nydalen, 0424 Oslo, Norway [3] Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blinde
  • Nesbakken A; 1] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway [3] Department of Gastrointestinal Surgery, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway.
  • Danielsen HE; 1] Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway [2] Centre for Cancer Biomedicine, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway [3] Department of Informatics, University of Oslo, PO Box 1080 Blindern, 0316 Oslo, Norway
Br J Cancer ; 110(8): 2159-64, 2014 Apr 15.
Article en En | MEDLINE | ID: mdl-24642618
ABSTRACT

BACKGROUND:

The prognostic impact of an indication of chromosomal instability (CIN) is evaluated in a consecutive series of 952 colorectal cancer patients treated at Aker University Hospital, Norway, during 1993-2003. Microsatellite instability (MSI) in this case series has recently been reported and made it possible to find the co-occurrence and compare the prognostic significance of CIN and MSI.

METHODS:

Data sets for overall survival (OS; n=855) and time to recurrence (TTR; n=579) were studied. To reveal CIN we used automated image cytometry (ICM). Non-diploid histograms were taken as indicative of the presence of CIN. PCR-based measures of MSI in this material have already been described.

RESULTS:

As with MSI, CIN was found to be an independent predictor of early relapse and death among stage II patients (TTR n=278 HR 2.19 (95% CI 1.35-3.55), P=0.002). Of the MSI tumours (16%), 71% were found to be DNA diploid, 21% were DNA tetraploid and 8% were DNA aneuploid. Among microsatellite stable tumours, 24% were DNA diploid, 15% were DNA tetraploid and 61% were DNA aneuploid.

CONCLUSION:

For patients presenting with stage II disease, genomic instability as detected by DNA image cytometry has the potential to provide a useful biomarker for relapse and cancer-related death following surgery with curative intent.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pronóstico / Neoplasias Colorrectales / Inestabilidad de Microsatélites Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Cancer Año: 2014 Tipo del documento: Article País de afiliación: Noruega
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pronóstico / Neoplasias Colorrectales / Inestabilidad de Microsatélites Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Cancer Año: 2014 Tipo del documento: Article País de afiliación: Noruega