Sphingolipids in ocular inflammation.
Adv Exp Med Biol
; 801: 623-9, 2014.
Article
en En
| MEDLINE
| ID: mdl-24664751
ABSTRACT
Sphingolipids are essential to cell membrane structure and the development and maintenance of neural tissues. The role of bioactive sphingolipids has been established in numerous cellular events, including cell survival, growth, and apoptosis. Ocular inflammatory and autoimmune diseases involve activation and migration of endothelial cells, neovascularization, and infiltration of immune cells into various tissues. Clinically, the impact and role of sphingolipid-mediated signaling is increasingly being appreciated in the pathogenesis and treatment of diseases ranging from multiple sclerosis to neovascularization in age-related macular degeneration and diabetic retinopathy. In this review, we discuss our current knowledge and understanding of sphingolipid metabolism and signaling associated with the pathogenesis of ocular diseases.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de la Retina
/
Esfingolípidos
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Uveítis
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Neovascularización Coroidal
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Degeneración Macular
Límite:
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
2014
Tipo del documento:
Article