Your browser doesn't support javascript.
loading
Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma.
Yuan, Sheng-Xian; Tao, Qi-Fei; Wang, Jie; Yang, Fu; Liu, Lei; Wang, Li-Li; Zhang, Jin; Yang, Yuan; Liu, Hui; Wang, Fang; Sun, Shu-Han; Zhou, Wei-Ping.
Afiliación
  • Yuan SX; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: yuanshengx@126.com.
  • Tao QF; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: tqftxl@163.com.
  • Wang J; Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Electronic address: msswjw@163.com.
  • Yang F; Department of Medical Genetics, Second Military Medical University, Shanghai, China. Electronic address: yangfusq1997@hotmail.com.
  • Liu L; Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Electronic address: leiliu@sibs.ac.cn.
  • Wang LL; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: 362769189@qq.com.
  • Zhang J; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: Zhangjin_sh@126.com.
  • Yang Y; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: yangyuan.ehbh@gmail.com.
  • Liu H; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: liuhuigg@hotmail.com.
  • Wang F; Department of Medical Genetics, Second Military Medical University, Shanghai, China. Electronic address: wfsjz70@gmail.com.
  • Sun SH; Department of Medical Genetics, Second Military Medical University, Shanghai, China. Electronic address: shsun@vip.sina.com.
  • Zhou WP; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: ehphwp3@126.com.
Cancer Lett ; 349(1): 87-94, 2014 Jul 10.
Article en En | MEDLINE | ID: mdl-24704293
ABSTRACT
About 61-72% of transcribed regions possess long noncoding RNAs in antisense orientation (Antisense long noncoding RNAs, aslncRNAs). However, the function of aslncRNAs in HCC remains unclear. We found numerous aslncRNAs were deregulated and might be involved in regulatory gene-net of HCC. The PCNA-AS1, antisense to PCNA, is significantly up-regulated in HCC and could promote tumor growth in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability. We concluded that aslncRNAs might act as upstream regulators in HCC and PCNA-AS1 could serve as a novel therapeutic target.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ARN sin Sentido / Carcinoma Hepatocelular / Antígeno Nuclear de Célula en Proliferación / ARN Largo no Codificante / Neoplasias Hepáticas Límite: Animals / Humans / Male Idioma: En Revista: Cancer Lett Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ARN sin Sentido / Carcinoma Hepatocelular / Antígeno Nuclear de Célula en Proliferación / ARN Largo no Codificante / Neoplasias Hepáticas Límite: Animals / Humans / Male Idioma: En Revista: Cancer Lett Año: 2014 Tipo del documento: Article