Region-specific DNA alterations in focally induced seizures.
J Neural Transm (Vienna)
; 121(11): 1399-403, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-24748548
ABSTRACT
We induced brief secondarily generalized seizures of limbic origin in Sprague-Dawley rats by bicuculline microinfusion into the anterior piriform cortex. After 1 h or 5 days we performed comet assay, a sensitive marker for DNA damage, within entorhinal cortex, hippocampus (limbic areas recruited by seizure spreading) and striatum (which is not recruited). DNA damage occurred selectively in the ipsilateral entorhinal cortex and hippocampus at 1 h, but not at 5 days. These data shed new light on molecular genetics as a marker during limbic seizures, the most common in epileptic patients.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Daño del ADN
/
Encéfalo
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Neural Transm (Vienna)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia