Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus.
J Gen Virol
; 95(Pt 8): 1647-1653, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-24828330
ABSTRACT
Bokeloh bat lyssavirus (BBLV), a novel lyssavirus, was isolated from a Natterer's bat (Myotis nattererii), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and human health are unknown and as such characterization both in vitro and in vivo was required to assess pathogenicity and vaccine protection. Full genome sequence analysis and antigenic cartography demonstrated that the German BBLV isolates are most closely related to European bat lyssavirus type 2 (EBLV-2) and Khujand virus and can be characterized within phylogroup I. In vivo characterization demonstrated that BBLV was pathogenic in mice when inoculated peripherally causing clinical signs typical for rabies encephalitis, with higher pathogenicity observed in juvenile mice. A limited vaccination-challenge experiment in mice was conducted and suggested that current vaccines would afford some protection against BBLV although further studies are warranted to determine a serological cut-off for protection.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN Viral
/
Quirópteros
/
Genoma Viral
/
Lyssavirus
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Gen Virol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Alemania