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Unique recurrence patterns of cervical intraepithelial neoplasia after excision of the squamocolumnar junction.
Herfs, Michael; Somja, Joan; Howitt, Brooke E; Suarez-Carmona, Meggy; Kustermans, Gaelle; Hubert, Pascale; Doyen, Jean; Goffin, Frederic; Kridelka, Frederic; Crum, Christopher P; Delvenne, Philippe.
Afiliación
  • Herfs M; Department of Pathology, Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium.
Int J Cancer ; 136(5): 1043-52, 2015 Mar 01.
Article en En | MEDLINE | ID: mdl-24839092
ABSTRACT
Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamocolumnar junction (SCJ) and suggest that these cells may not regenerate after excision (loop electrosurgical excision procedure). Our study addressed the impact of SCJ excision on the temporal dynamics, histologic and viral (human papillomavirus, HPV) characteristics of recurrent CIN. One hundred and thirty-one consecutive patients treated by excision and attending follow-up visits were enrolled. We compared recurrent and initial CIN with attention to excision margins, timing of recurrence, CIN grade, HPV types, p16 immunophenotype and SCJ immunophenotype. During the follow-up period (up to 4 years), 16 (12.2%) recurrences were identified. Four (25%) were identified at the first follow-up visit, closely resembled the initial CIN 2/3 in grade and HPV type and were typically SCJ marker positive [SCJ(+)], suggesting nonexcised (residual) disease. Twelve (75%) manifested after the first postoperative visit and all were in the ectocervix or in mature metaplastic epithelium. All of the 12 delayed recurrences were classified as CIN 1 and were SCJ (-). In total, 9 out of 11 SCJ (-) recurrences (82%) followed regressed spontaneously. Taken together, these results show that new lesions developing from any HPV infection are delayed and occur within the ectocervix or metaplastic epithelium. This markedly lower risk of CIN 2/3 after successful SCJ excision suggests that the removal of the SCJ could be a critical variable in reducing the risk of subsequent CIN 2/3 and cervical cancer.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Neoplasias de Células Escamosas / Neoplasia Residual / Infecciones por Papillomavirus / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Int J Cancer Año: 2015 Tipo del documento: Article País de afiliación: Bélgica

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Neoplasias de Células Escamosas / Neoplasia Residual / Infecciones por Papillomavirus / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Int J Cancer Año: 2015 Tipo del documento: Article País de afiliación: Bélgica