Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells.
EMBO J
; 33(12): 1354-64, 2014 Jun 17.
Article
en En
| MEDLINE
| ID: mdl-24843045
ABSTRACT
Organization of immune responses requires exchange of information between cells. This is achieved through either direct cell-cell contacts and establishment of temporary synapses or the release of soluble factors, such as cytokines and chemokines. Here we show a novel form of cell-to-cell communication based on adenosine triphosphate (ATP). ATP released by stimulated T cells induces P2X4/P2X7-mediated calcium waves in the neighboring lymphocytes. Our data obtained in lymph node slices suggest that, during T-cell priming, ATP acts as a paracrine messenger to reduce the motility of lymphocytes and that this may be relevant to allow optimal tissue scanning by T cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Movimiento Celular
/
Adenosina Trifosfato
/
Calcio
/
Modelos Inmunológicos
/
Comunicación Paracrina
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
EMBO J
Año:
2014
Tipo del documento:
Article