Your browser doesn't support javascript.
loading
miRNA modulation of SOCS1 using an influenza A virus delivery system.
Izzard, Leonard; Ye, Siying; Jenkins, Kristie; Xia, Yingju; Tizard, Mark; Stambas, John.
Afiliación
  • Izzard L; School of Medicine, Deakin University, Geelong, Victoria, Australia.
  • Ye S; School of Medicine, Deakin University, Geelong, Victoria, Australia.
  • Jenkins K; CSIRO, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
  • Xia Y; School of Medicine, Deakin University, Geelong, Victoria, Australia.
  • Tizard M; CSIRO, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
  • Stambas J; School of Medicine, Deakin University, Geelong, Victoria, Australia.
J Gen Virol ; 95(Pt 9): 1880-1885, 2014 Sep.
Article en En | MEDLINE | ID: mdl-24876306
ABSTRACT
Difficulties associated with efficient delivery and targeting of miRNAs to cells is hampering the real world application of miRNA technology. This study utilized an influenza A-based delivery system to express miR-155 in order to knockdown SOCS1 mRNA. Using qPCR and dual luciferase technology we show that miR-155 delivery resulted in a significant increase in cellular miR-155 which facilitated a downregulation of SOCS1 gene expression and a functional increase in IL-6 and IFN-ß cytokines.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Influenza A / Técnicas de Transferencia de Gen / MicroARNs / Proteínas Supresoras de la Señalización de Citocinas Límite: Animals Idioma: En Revista: J Gen Virol Año: 2014 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Influenza A / Técnicas de Transferencia de Gen / MicroARNs / Proteínas Supresoras de la Señalización de Citocinas Límite: Animals Idioma: En Revista: J Gen Virol Año: 2014 Tipo del documento: Article País de afiliación: Australia