Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode.

Huang, Xiaohua; Cheng, Cliff C; Fischmann, Thierry O; Duca, José S; Yang, Xianshu; Richards, Matthew; Shipps, Gerald W

Huang, Xiaohua; Cheng, Cliff C; Fischmann, Thierry O; Duca, José S; Yang, Xianshu; Richards, Matthew; Shipps, Gerald W.

Afiliación

Huang X; Merck Research Laboratories , 320 Bent Street, Cambridge, Massachusetts 02141, United States.
Cheng CC; Merck Research Laboratories , 320 Bent Street, Cambridge, Massachusetts 02141, United States.
Fischmann TO; Merck Research Laboratories , 320 Bent Street, Cambridge, Massachusetts 02141, United States.
Duca JS; Merck Research Laboratories , 320 Bent Street, Cambridge, Massachusetts 02141, United States.
Yang X; Merck Research Laboratories , 320 Bent Street, Cambridge, Massachusetts 02141, United States.
Richards M; Merck Research Laboratories , 320 Bent Street, Cambridge, Massachusetts 02141, United States.
Shipps GW; Merck Research Laboratories , 320 Bent Street, Cambridge, Massachusetts 02141, United States.

ACS Med Chem Lett ; 3(2): 123-8, 2012 Feb 09.

Article en En | MEDLINE | ID: mdl-24900442

Palabras clave

Automated Ligand Identification System (ALIS); CHK1 protein kinase; affinity selection−mass spectrometry (AS-MS); structure-based drug design; thiazole-4-carboxamide

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos

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