Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 24(14): 3092-5, 2014 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-24907145
ABSTRACT
The first synthesis of 1'-cyano-2'-C-methyl pyrimidine nucleosides is described. Anti-HCV activity of these nucleosides and their nucleotide phosphoramidate prodrugs was assessed and compared to the 1'-unsubstituted counterparts and to the related 1'-cyano-2'-C-methyl C-nucleoside parent of GS-6620.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Nucleósidos de Pirimidina
/
ARN Polimerasa Dependiente del ARN
/
Proteínas no Estructurales Virales
/
Hepacivirus
/
Inhibidores Enzimáticos
/
Nucleósidos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2014
Tipo del documento:
Article