Recombinant alpha-2a interferon plus vinblastine in the treatment of metastatic renal cell carcinoma.
Am J Clin Oncol
; 12(1): 43-5, 1989 Feb.
Article
en En
| MEDLINE
| ID: mdl-2492141
Twenty consecutive metastatic renal cell carcinoma patients were treated with a combination of recombinant alpha-2a interferon (18 X 10(6) U three times weekly) and vinblastine (0.1 mg/kg every 3 weeks). Two patients (10% response rate; 95% confidence limits 1.23-31.7%) achieved partial response and 11 (55%) stable disease. Toxicity was significant but always acceptable: most frequently, patients complained of fever and flu-like symptoms (18 of 19 patients), fatigue (18 of 19 patients), worsening in performance status (15 of 19 patients), and anorexia (15 of 19). The combination of recombinant alpha-2a interferon and vinblastine is active in renal cell carcinoma.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vinblastina
/
Carcinoma de Células Renales
/
Interferón gamma
/
Neoplasias Renales
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Clin Oncol
Año:
1989
Tipo del documento:
Article
País de afiliación:
Italia