The role of type I interferons in intestinal infection, homeostasis, and inflammation.
Immunol Rev
; 260(1): 145-67, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24942688
ABSTRACT
Type I interferons are a widely expressed family of effector cytokines that promote innate antiviral and antibacterial immunity. Paradoxically, they can also suppress immune responses by driving production of anti-inflammatory cytokines, and dysregulation of these cytokines can contribute to host-mediated immunopathology and disease progression. Recent studies describe their anti-inflammatory role in intestinal inflammation and the locus containing IFNAR, a heterodimeric receptor for the type I interferons has been identified as a susceptibility region for human inflammatory bowel disease. This review focuses on the role of type I IFNs in the intestine in health and disease and their emerging role as immune modulators. Clear understanding of type I IFN-mediated immune responses may provide avenues for fine-tuning existing IFN treatment for infection and intestinal inflammation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Interferón Tipo I
/
Homeostasis
/
Inflamación
/
Mucosa Intestinal
/
Intestinos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Rev
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos