On conductivity, permittivity, apparent diffusion coefficient, and their usefulness as cancer markers at MRI frequencies.
Magn Reson Med
; 73(5): 2025-9, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-24946752
ABSTRACT
PURPOSE:
To investigate the permittivity and conductivity of cancerous and normal tissues, their correlation to the apparent diffusion coefficient (ADC), and the specificity that they could add to cancer detection. THEORY Breast and prostate carcinomas were induced in rats. Conductivity and permittivity measurements were performed in the anesthetized animals using a dielectric probe and an impedance analyzer between 50 and 270 MHz. The correlations between ADCs (measured at 128 MHz) and conductivity values were investigated. Frequency-dependent discriminant functions were computed to assess the value that each parameter adds to cancer detection.METHODS:
Tumors exhibited higher permittivity than muscle tissue by 27%/12%/5% at 64/128/270MHz. Frequency independent, 15-20% higher conductivity was also noted in tumors compared to muscle tissue over the same frequency range. Strong negative correlation was observed between tissue conductivity and ADC. Whereas permittivity had the strongest discriminatory power at 64 MHz, it became comparable to ADC at 128 MHz and less important than ADC at 270 MHz.CONCLUSION:
Conductivity measurements offered limited advantages in separating cancer from normal tissue beyond what ADC already provided; conversely, permittivity added separation power when added to the discriminant function. The moderately high cancerous tissue permittivity and conductivity impose strong constraints on the capability of MRI-based tissue electrical property measurements.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Procesamiento de Imagen Asistido por Computador
/
Aumento de la Imagen
/
Adenocarcinoma
/
Biomarcadores de Tumor
/
Imagen de Difusión por Resonancia Magnética
/
Neoplasias Mamarias Experimentales
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Magn Reson Med
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos