Yellow fever risk assessment in the Central African Republic.
Trans R Soc Trop Med Hyg
; 108(10): 608-15, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-24947520
ABSTRACT
BACKGROUND:
Starting in 2008, the Central African Republic (CAR) experienced an unprecedented number of reported yellow fever (YF) cases. A risk assessment of YF virus (YFV) activity was conducted to estimate potential disease risk and vaccine needs.METHODS:
A multistage cluster sampling design was used to sample humans, non-human primates, and mosquitoes in distinct ecologic zones. Humans and non-human primates were tested for YFV-specific antibodies; mosquitoes were tested for YFV RNA.RESULTS:
Overall, 13.3% (125/938) of humans were found to have naturally-acquired YFV antibodies. Antibody levels were higher in zones in the southern and south central regions of CAR. All sampled non-human primates (n=56) were known YFV reservoirs; one tested positive for YFV antibodies. Several known YF vectors were identified including Aedes africanus, Ae. aegypti, Ae. luteocephalus, and Ae. simpsoni. Several more urban locations were found to have elevated Breateau and Container indices for Ae. aegypti.CONCLUSIONS:
A country-wide assessment of YF risk found YFV to be endemic in CAR. The potential for future YF cases and outbreaks, however, varied by ecologic zone. Improved vaccination coverage through mass campaign and childhood immunization was recommended to mitigate the YF risk.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fiebre Amarilla
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Animals
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos