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Viral fitness does not correlate with three genotype displacement events involving infectious hematopoietic necrosis virus.
Kell, Alison M; Wargo, Andrew R; Kurath, Gael.
Afiliación
  • Kell AM; University of Washington, Seattle, WA, USA; U.S. Geological Survey, Western Fisheries Research Center, Seattle, WA, USA. Electronic address: kella@uw.edu.
  • Wargo AR; University of Washington, Seattle, WA, USA; U.S. Geological Survey, Western Fisheries Research Center, Seattle, WA, USA.
  • Kurath G; University of Washington, Seattle, WA, USA; U.S. Geological Survey, Western Fisheries Research Center, Seattle, WA, USA.
Virology ; 464-465: 146-155, 2014 Sep.
Article en En | MEDLINE | ID: mdl-25068402
Viral genotype displacement events are characterized by the replacement of a previously dominant virus genotype by a novel genotype of the same virus species in a given geographic region. We examine here the fitness of three pairs of infectious hematopoietic necrosis virus (IHNV) genotypes involved in three major genotype displacement events in Washington state over the last 30 years to determine whether increased virus fitness correlates with displacement. Fitness was assessed using in vivo assays to measure viral replication in single infection, simultaneous co-infection, and sequential superinfection in the natural host, steelhead trout. In addition, virion stability of each genotype was measured in freshwater and seawater environments at various temperatures. By these methods, we found no correlation between increased viral fitness and displacement in the field. These results suggest that other pressures likely exist in the field with important consequences for IHNV evolution.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Rhabdoviridae / Virus de la Necrosis Hematopoyética Infecciosa / Enfermedades de los Peces Límite: Animals Idioma: En Revista: Virology Año: 2014 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Rhabdoviridae / Virus de la Necrosis Hematopoyética Infecciosa / Enfermedades de los Peces Límite: Animals Idioma: En Revista: Virology Año: 2014 Tipo del documento: Article