NLRP7 inter-domain interactions: the NACHT-associated domain is the physical mediator for oligomeric assembly.

Singer, Heike; Biswas, Arijit; Zimmer, Nicole; Messaed, Christiane; Oldenburg, Johannes; Slim, Rima; El-Maarri, Osman

Singer, Heike; Biswas, Arijit; Zimmer, Nicole; Messaed, Christiane; Oldenburg, Johannes; Slim, Rima; El-Maarri, Osman.

Afiliación

Singer H; Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany.
Biswas A; Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany.
Zimmer N; Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany.
Messaed C; Department of Human Genetics, McGill University Health Centre Research Institute, Montreal, Canada Department of Obstetrics and Gynecology, McGill University Health Centre Research Institute, Montreal, Canada.
Oldenburg J; Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany.
Slim R; Department of Human Genetics, McGill University Health Centre Research Institute, Montreal, Canada Department of Obstetrics and Gynecology, McGill University Health Centre Research Institute, Montreal, Canada.
El-Maarri O; Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany osman.elmaarri@ukb.uni-bonn.de.

Mol Hum Reprod ; 20(10): 990-1001, 2014 Oct.

Article en En | MEDLINE | ID: mdl-25082979

Asunto(s)

Proteínas Adaptadoras Transductoras de Señales/genética; Mola Hidatiforme/genética; Pliegue de Proteína; Deficiencias en la Proteostasis/genética; Línea Celular; Femenino; Células HEK293; Humanos; Modelos Moleculares; Mutación Missense; NAD/genética; Placentación; Embarazo; Agregación Patológica de Proteínas/genética; Isoformas de Proteínas/genética; Estructura Terciaria de Proteína; Técnicas del Sistema de Dos Híbridos

Palabras clave

HYDM1-causing mutations; NLRP7; aggresome; inter-domain-interactions; protein misfolding

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Mola Hidatiforme / Pliegue de Proteína / Proteínas Adaptadoras Transductoras de Señales / Deficiencias en la Proteostasis Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Mol Hum Reprod Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA REPRODUTIVA Año: 2014 Tipo del documento: Article País de afiliación: Alemania

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