Trophoblast-specific reduction of VEGFA alters placental gene expression and maternal cardiovascular function in mice.

Li, Han; Qu, Dawei; McDonald, Angela; Isaac, Sarah M; Whiteley, Kathie J; Sung, Hoon-Ki; Nagy, Andras; Adamson, S Lee

Li, Han; Qu, Dawei; McDonald, Angela; Isaac, Sarah M; Whiteley, Kathie J; Sung, Hoon-Ki; Nagy, Andras; Adamson, S Lee.

Afiliación

Li H; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Qu D; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
McDonald A; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Isaac SM; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Whiteley KJ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Sung HK; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Nagy A; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.
Adamson SL; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada Department of Physiology, University of Toronto, Toronto, Ontario, Canada Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada adamson@lunenfeld.ca.

Biol Reprod ; 91(4): 87, 2014 Oct.

Article en En | MEDLINE | ID: mdl-25122061

Asunto(s)

Placenta/metabolismo; Trofoblastos/metabolismo; Factor A de Crecimiento Endotelial Vascular/metabolismo; Animales; Linaje de la Célula; Femenino; Eliminación de Gen; Regulación de la Expresión Génica/fisiología; Integrasas/genética; Integrasas/metabolismo; Intercambio Materno-Fetal; Ratones; Ratones Transgénicos; Placenta/citología; Circulación Placentaria/fisiología; Embarazo; Proteínas Gestacionales/genética; Proteínas Gestacionales/metabolismo; Factor A de Crecimiento Endotelial Vascular/genética

Palabras clave

Cre-loxP; Flt1; Kdr; Prl3b1; VEGF-A; blood pressure; cardiac output; decidua; embryo loss; hypotension; junctional zone; labyrinth; placenta; placental circulation; placental hormones; placental lactogen; pregnancy; sFlt1; spongiotrophoblast; transgenic mice; vascular endothelial growth factor; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Placenta / Trofoblastos / Factor A de Crecimiento Endotelial Vascular Límite: Animals / Pregnancy Idioma: En Revista: Biol Reprod Año: 2014 Tipo del documento: Article País de afiliación: Canadá

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