Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 58(11): 6962-5, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25155596
ABSTRACT
We report here a series of five chemically diverse scaffolds that have in vitro activities on replicating and hypoxic nonreplicating bacilli by targeting the respiratory bc1 complex in Mycobacterium tuberculosis in a strain-dependent manner. Deletion of the cytochrome bd oxidase generated a hypersusceptible mutant in which resistance was acquired by a mutation in qcrB. These results highlight the promiscuity of the bc1 complex and the risk of targeting energy metabolism with new drugs.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Complejo IV de Transporte de Electrones
/
Farmacorresistencia Bacteriana Múltiple
/
Mycobacterium tuberculosis
/
Antituberculosos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos