[Relationship between vascular senescence and impaired circadian rhythmicity].
Nihon Rinsho
; 72(8): 1419-23, 2014 Aug.
Article
en Ja
| MEDLINE
| ID: mdl-25167746
ABSTRACT
Aging is associated with impairment of various circadian rhythms of body, including daily rhythms of blood pressure, core body temperature, and the sleep-waking cycle. In mammals circadian rhythmicity is under control of molecular pacemaker that is composed of products of clock genes. Recent evidence suggests that cellular senescence impairs circadian rhythmicity and contributes to various age-associated diseases. Senescence decreases the ability of cells to transmit circadian signals such as nitric oxide to their clocks. The regulation of clock gene expression may be a novel strategy for treatment of age-associated impairment of circadian rhythmicity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sueño
/
Relojes Biológicos
/
Circulación Sanguínea
/
Ritmo Circadiano
/
Senescencia Celular
Límite:
Animals
/
Humans
Idioma:
Ja
Revista:
Nihon Rinsho
Año:
2014
Tipo del documento:
Article