[Effects of bisphenol-A on blastocyst development and implantation].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 36(4): 351-6, 2014 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-25176201
ABSTRACT
OBJECTIVE:
To determine the effects of bisphenol-A (BPA) on blastocyst development and implantation.METHODS:
According to completely randomized grouping method, 90 pregnant mice were divided into 100, 300, and 600 mg/(kg·d)BPA groups and control group. BPA-treated pregnant mice were orally administered with BPA at concentrations of 100, 300 and 600 mg/(kg·d) from day 0.5 to day 3.5 of their pregnancy. Blastocyst implantation and development were studied.RESULTS:
In the 300 mg/(kg·d) BPA group, the number of implantation sites and implantation rate were significantly decreased. In the 600 mg/(kg·d) group, no implantation sites were observed among pregnant mice and BPA inhibited embryo implantation. Blastocyst development on day 4 was examined, and findings showed that the development rate and total numbers of blastocysts in BPA treatment groups had no significant difference from the control group. However, BPA at 300 and 600 mg/(kg·d) significantly reduced blastocyst hatching rate and dramatically increased the number of blastocyst apoptotic cells when compared with those in the control group.CONCLUSION:
BPA at a high concentration damages the blastocyst development before implantation and inhibits embryo implantation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Implantación del Embrión
/
Fenoles
/
Compuestos de Bencidrilo
/
Blastocisto
Límite:
Animals
/
Pregnancy
Idioma:
Zh
Revista:
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Año:
2014
Tipo del documento:
Article
País de afiliación:
China