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Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA.
Stradling, J R; Craig, S E; Kohler, M; Nicoll, D; Ayers, L; Nunn, A J; Bratton, D J.
Afiliación
  • Stradling JR; Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
  • Craig SE; Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
  • Kohler M; Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland.
  • Nicoll D; Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
  • Ayers L; Department of Clinical Immunology, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
  • Nunn AJ; MRC Clinical Trials Unit at UCL, Aviation House, London, UK.
  • Bratton DJ; MRC Clinical Trials Unit at UCL, Aviation House, London, UK.
Thorax ; 70(2): 181-2, 2015 Feb.
Article en En | MEDLINE | ID: mdl-25182045
ABSTRACT
UNLABELLED The Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular (MOSAIC) trial compared 6 months of CPAP therapy, versus no CPAP, in 391 patients with minimally symptomatic obstructive sleep apnoea (OSA). We now report some exploratory outcomes, markers of systemic inflammation (interleukin 6 (IL-6), IL-10, C reactive protein, tumour necrosis factor). We found no consistent changes (all p values >0.13). TRIAL REGISTRATION NUMBER ISRCTN 34164388.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Interleucina-6 / Factor de Necrosis Tumoral alfa / Interleucina-10 / Apnea Obstructiva del Sueño / Inflamación Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Thorax Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Interleucina-6 / Factor de Necrosis Tumoral alfa / Interleucina-10 / Apnea Obstructiva del Sueño / Inflamación Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Thorax Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido