Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.

Westphal, Dana; Dewson, Grant; Menard, Marie; Frederick, Paul; Iyer, Sweta; Bartolo, Ray; Gibson, Leonie; Czabotar, Peter E; Smith, Brian J; Adams, Jerry M; Kluck, Ruth M

Westphal, Dana; Dewson, Grant; Menard, Marie; Frederick, Paul; Iyer, Sweta; Bartolo, Ray; Gibson, Leonie; Czabotar, Peter E; Smith, Brian J; Adams, Jerry M; Kluck, Ruth M.

Afiliación

Westphal D; Molecular Genetics of Cancer Division, Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; and.
Dewson G; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; and Cell Signalling and Cell Death Division, and.
Menard M; Molecular Genetics of Cancer Division.
Frederick P; Molecular Genetics of Cancer Division.
Iyer S; Molecular Genetics of Cancer Division, Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; and.
Bartolo R; Molecular Genetics of Cancer Division.
Gibson L; Molecular Genetics of Cancer Division.
Czabotar PE; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; and Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;
Smith BJ; School of Molecular Sciences, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, VIC 3086, Australia.
Adams JM; Molecular Genetics of Cancer Division, Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; and adams@wehi.edu.au kluck@wehi.edu.au.
Kluck RM; Molecular Genetics of Cancer Division, Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; and adams@wehi.edu.au kluck@wehi.edu.au.

Proc Natl Acad Sci U S A ; 111(39): E4076-85, 2014 Sep 30.

Article en En | MEDLINE | ID: mdl-25228770

Asunto(s)

Apoptosis/fisiología; Membranas Mitocondriales/metabolismo; Proteína Destructora del Antagonista Homólogo bcl-2/química; Proteína Destructora del Antagonista Homólogo bcl-2/metabolismo; Proteína X Asociada a bcl-2/química; Proteína X Asociada a bcl-2/metabolismo; Secuencia de Aminoácidos; Sustitución de Aminoácidos; Animales; Línea Celular; Cisteína/química; Humanos; Ratones; Membranas Mitocondriales/química; Modelos Moleculares; Datos de Secuencia Molecular; Mutagénesis Sitio-Dirigida; Estructura Cuaternaria de Proteína; Estructura Secundaria de Proteína; Estructura Terciaria de Proteína; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Estilbenos; Reactivos de Sulfhidrilo; Proteína Destructora del Antagonista Homólogo bcl-2/genética; Proteína X Asociada a bcl-2/genética

Palabras clave

cell death; cysteine-scanning mutagenesis; membrane pores; mitochondrial permeabilization; protein-membrane topology

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Membranas Mitocondriales / Proteína X Asociada a bcl-2 / Proteína Destructora del Antagonista Homólogo bcl-2 Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2014 Tipo del documento: Article

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