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Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.
Greaves, Laura C; Nooteboom, Marco; Elson, Joanna L; Tuppen, Helen A L; Taylor, Geoffrey A; Commane, Daniel M; Arasaradnam, Ramesh P; Khrapko, Konstantin; Taylor, Robert W; Kirkwood, Thomas B L; Mathers, John C; Turnbull, Douglass M.
Afiliación
  • Greaves LC; Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Nooteboom M; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Elson JL; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Centre for Human Metabolomics, North-West University, Potchefstroom, South Africa.
  • Tuppen HA; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Taylor GA; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Commane DM; Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Arasaradnam RP; Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Khrapko K; Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
  • Taylor RW; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Kirkwood TB; Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.
  • Mathers JC; Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Turnbull DM; Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
PLoS Genet ; 10(9): e1004620, 2014 Sep.
Article en En | MEDLINE | ID: mdl-25232829
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / ADN Mitocondrial / Mutación Puntual / Mitocondrias Tipo de estudio: Diagnostic_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / ADN Mitocondrial / Mutación Puntual / Mitocondrias Tipo de estudio: Diagnostic_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido