[Morphogenesis of the stromal tissue of nasal polyps].

ABSTRACT

The objective of the present work was to study various stages of morphogenesis of the stromal tissue of nasal polyps. The materials for the investigation were harvested during endoscopic polypotomies in the nose. They were used to obtain the preparations that were stained by the histological and histochemical methods. The immunochemical studies were carried out using monoclonal antibodies against differentiation clusters, such as CD20, CD31, and vascular endothelial growth factor (VEGF). The study has demonstrated that the growth and evolution of the nasal polyps are accompanied by sequential alterations in the morphological structure of their stromal tissue. The results of the investigations were used to develop the original classification of the selected stages of morphogenesis of the stromal tissue of nasal polyps. The following stages were distinguished edematous one, inflammatory cellular infiltration, fibrous cirrhotic alterations, and vasculogenesis or neoangiogenesis.