Bmi-1 regulates the migration and invasion of glioma cells through p16.
Cell Biol Int
; 39(3): 283-90, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25262972
ABSTRACT
Bmi-1 is involved in the development of several human cancers; however, its significance in glioma progression remains largely unknown. We report that downregulation of Bmi-1 clearly reduces glioma cell migration and invasion. Downregulation of Bmi-1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation. These results show that Bmi-1 contributes to the motility of glioma cells by regulating the expression of p16.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Inhibidor p16 de la Quinasa Dependiente de Ciclina
/
Complejo Represivo Polycomb 1
/
Glioma
Límite:
Humans
Idioma:
En
Revista:
Cell Biol Int
Año:
2015
Tipo del documento:
Article