The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.

Yamazaki, Toyomi; Sagisaka, Miki; Ikeda, Riko; Nakamura, Toshiyuki; Matsuda, Noriko; Ishii, Takeshi; Nakayama, Tsutomu; Watanabe, Tatsuo

Yamazaki, Toyomi; Sagisaka, Miki; Ikeda, Riko; Nakamura, Toshiyuki; Matsuda, Noriko; Ishii, Takeshi; Nakayama, Tsutomu; Watanabe, Tatsuo.

Afiliación

Yamazaki T; a Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka , Shizuoka , Japan.

Biosci Biotechnol Biochem ; 78(10): 1753-6, 2014.

Article en En | MEDLINE | ID: mdl-25273142

RESUMEN

We purified several hundred mgs of four major theaflavins (theaflavin, theaflavin-3-O-gallate, theaflavin-3'-O-gallate, and theaflavin-3,3'-O-digallate). Among the 25 hTAS2Rs expressed in HEK293T cells, hTAS2R39 and hTAS2R14 were activated by theaflavins. Both hTAS2R39 and hTAS2R14 responded to theaflavin-3'-O-gallate. In addition, hTAS2R39 was activated by theaflavin and theaflavin-3,3'-O-gallate, but not by theaflavin-3-O-gallate. In contrast, hTAS2R14 responded to theaflavin-3-O-gallate.

Asunto(s)

Biflavonoides/metabolismo; Biflavonoides/farmacología; Catequina/metabolismo; Catequina/farmacología; Receptores de Superficie Celular/metabolismo; Percepción del Gusto/efectos de los fármacos; Calcio/metabolismo; Células HEK293; Humanos

Palabras clave

human bitter taste receptor; human bitter taste receptor 14 (hTAS2R14); human bitter taste receptor 39 (hTAS2R39); theaflavins

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Catequina / Receptores de Superficie Celular / Biflavonoides / Percepción del Gusto Límite: Humans Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Japón

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