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Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.
Yang, Shu-Wei; Ho, Ginny D; Tulshian, Deen; Bercovici, Ana; Tan, Zheng; Hanisak, Jennifer; Brumfield, Stephanie; Matasi, Julius; Sun, Xianfeng; Sakwa, Samuel A; Herr, R Jason; Zhou, Xiaoping; Bridal, Terry; Urban, Mark; Vivian, Jeffrey; Rindgen, Diane; Sorota, Steve.
Afiliación
  • Yang SW; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States. Electronic address: shu-wei.yang@merck.com.
  • Ho GD; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Tulshian D; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Bercovici A; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Tan Z; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Hanisak J; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Brumfield S; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Matasi J; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Sun X; Department of Medicinal Chemistry, Albany Molecular Research, Inc. (AMRI), Albany, NY 12203, United States.
  • Sakwa SA; Department of Medicinal Chemistry, Albany Molecular Research, Inc. (AMRI), Albany, NY 12203, United States.
  • Herr RJ; Department of Medicinal Chemistry, Albany Molecular Research, Inc. (AMRI), Albany, NY 12203, United States.
  • Zhou X; In Vivo Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Bridal T; Cardiorenal Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Urban M; Neuroscience, Merck Research Laboratory, West Point, PA 19486, United States.
  • Vivian J; Neuroscience, Merck Research Laboratory, West Point, PA 19486, United States.
  • Rindgen D; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
  • Sorota S; Cardiorenal Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
Bioorg Med Chem Lett ; 24(21): 4958-62, 2014 Nov 01.
Article en En | MEDLINE | ID: mdl-25288187
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nervios Espinales / Compuestos de Espiro / Bloqueadores de los Canales de Sodio / Canal de Sodio Activado por Voltaje NAV1.7 / Ganglios Espinales / Analgésicos / Neuralgia Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nervios Espinales / Compuestos de Espiro / Bloqueadores de los Canales de Sodio / Canal de Sodio Activado por Voltaje NAV1.7 / Ganglios Espinales / Analgésicos / Neuralgia Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article