Novel amino-ß-lactam derivatives as potent cholesterol absorption inhibitors.

Drazic, Tonko; Molcanov, Kresimir; Sachdev, Vinay; Malnar, Martina; Hecimovic, Silva; Patankar, Jay V; Obrowsky, Sascha; Levak-Frank, Sanja; Habus, Ivan; Kratky, Dagmar

Drazic, Tonko; Molcanov, Kresimir; Sachdev, Vinay; Malnar, Martina; Hecimovic, Silva; Patankar, Jay V; Obrowsky, Sascha; Levak-Frank, Sanja; Habus, Ivan; Kratky, Dagmar.

Afiliación

Drazic T; Ruder Boskovic Institute, Bijenicka c. 54, HR-10002 Zagreb, Croatia. Electronic address: tdrazic@irb.hr.
Molcanov K; Ruder Boskovic Institute, Bijenicka c. 54, HR-10002 Zagreb, Croatia.
Sachdev V; Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Malnar M; Ruder Boskovic Institute, Bijenicka c. 54, HR-10002 Zagreb, Croatia.
Hecimovic S; Ruder Boskovic Institute, Bijenicka c. 54, HR-10002 Zagreb, Croatia.
Patankar JV; Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Obrowsky S; Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Levak-Frank S; Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Habus I; Ruder Boskovic Institute, Bijenicka c. 54, HR-10002 Zagreb, Croatia.
Kratky D; Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria. Electronic address: dagmar.kratky@medunigraz.at.

Eur J Med Chem ; 87: 722-34, 2014 Nov 24.

Article en En | MEDLINE | ID: mdl-25305716

Asunto(s)

Anticolesterolemiantes/farmacología; Colesterol/metabolismo; beta-Lactamas/farmacología; Animales; Anticolesterolemiantes/química; Cristalografía por Rayos X; Perros; Células Hep G2; Humanos; Concentración 50 Inhibidora; Células de Riñón Canino Madin Darby; Ratones; Estructura Molecular; Espectroscopía de Protones por Resonancia Magnética; beta-Lactamas/química

Palabras clave

Cardiovascular heart disease; Cholesterol absorption inhibitor; Hyperlipidemia; ß-lactam

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colesterol / Beta-Lactamas / Anticolesterolemiantes Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article

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