Early gene expression in salivary gland after isoproterenol treatment.
J Cell Biochem
; 116(3): 431-7, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25336019
ABSTRACT
Isoproterenol, a ß-adrenergic agonist, has been shown to induce salivary gland hyperplasia. However, the mechanism involved in this pharmacological phenomenon is not well understood. To gain a better understanding of the underlying changes, including genes, networks and pathways altered by isoproterenol, microarray-based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60 min after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time-dependent manner. Pathway analysis showed that cell hyperplasia, p38(MAPK), and IGF-1 were the most altered function, network and pathway, respectively. The balanced regulation of up- and down-expression of genes related to cell proliferation/survival may provide a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement without tumor transformation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Glándulas Salivales
/
Regulación de la Expresión Génica
/
Isoproterenol
Límite:
Animals
Idioma:
En
Revista:
J Cell Biochem
Año:
2015
Tipo del documento:
Article
País de afiliación:
China