Influenza promotes collagen deposition via &#945;vß6 integrin-mediated transforming growth factor ß activation.

Jolly, Lisa; Stavrou, Anastasios; Vanderstoken, Gilles; Meliopoulos, Victoria A; Habgood, Anthony; Tatler, Amanda L; Porte, Joanne; Knox, Alan; Weinreb, Paul; Violette, Shelia; Hussell, Tracy; Kolb, Martin; Stampfli, Martin R; Schultz-Cherry, Stacey; Jenkins, Gisli

Influenza promotes collagen deposition via αvß6 integrin-mediated transforming growth factor ß activation.

Jolly, Lisa; Stavrou, Anastasios; Vanderstoken, Gilles; Meliopoulos, Victoria A; Habgood, Anthony; Tatler, Amanda L; Porte, Joanne; Knox, Alan; Weinreb, Paul; Violette, Shelia; Hussell, Tracy; Kolb, Martin; Stampfli, Martin R; Schultz-Cherry, Stacey; Jenkins, Gisli.

Afiliación

Jolly L; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Stavrou A; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Vanderstoken G; the McMaster Immunology Research Centre and Firestone Institute at St. Joseph's Health Care, McMaster University, Hamilton, Ontario L8S4L8, Canada, and.
Meliopoulos VA; the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Habgood A; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Tatler AL; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Porte J; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Knox A; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Weinreb P; Biogen Idec Inc., Cambridge, Massachusetts 02142.
Violette S; Biogen Idec Inc., Cambridge, Massachusetts 02142.
Hussell T; the Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, United Kingdom.
Kolb M; the McMaster Immunology Research Centre and Firestone Institute at St. Joseph's Health Care, McMaster University, Hamilton, Ontario L8S4L8, Canada, and.
Stampfli MR; the McMaster Immunology Research Centre and Firestone Institute at St. Joseph's Health Care, McMaster University, Hamilton, Ontario L8S4L8, Canada, and.
Schultz-Cherry S; the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Jenkins G; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom, gisli.jenkins@nottingham.ac.uk.

J Biol Chem ; 289(51): 35246-63, 2014 Dec 19.

Article en En | MEDLINE | ID: mdl-25339175

Asunto(s)

Antígenos de Neoplasias/metabolismo; Colágeno/metabolismo; Células Epiteliales/metabolismo; Integrinas/metabolismo; Infecciones por Orthomyxoviridae/metabolismo; Factor de Crecimiento Transformador beta/metabolismo; 1-(5-Isoquinolinesulfonil)-2-Metilpiperazina/análogos & derivados; 1-(5-Isoquinolinesulfonil)-2-Metilpiperazina/farmacología; Animales; Antígenos de Neoplasias/genética; Antivirales/farmacología; Apoptosis; Línea Celular Transformada; Perros; Células Epiteliales/efectos de los fármacos; Células Epiteliales/virología; Interacciones Huésped-Patógeno; Humanos; Immunoblotting; Subtipo H1N1 del Virus de la Influenza A/fisiología; Integrinas/genética; Pulmón/metabolismo; Pulmón/virología; Células de Riñón Canino Madin Darby; Ratones Endogámicos C57BL; Ratones Noqueados; Infecciones por Orthomyxoviridae/genética; Infecciones por Orthomyxoviridae/virología; Fosforilación/efectos de los fármacos; Poli I-C/farmacología; Proteína smad3/genética; Proteína smad3/metabolismo; Receptor Toll-Like 3/metabolismo; Factor de Crecimiento Transformador beta/genética; Quinasas Asociadas a rho/antagonistas & inhibidores; Quinasas Asociadas a rho/metabolismo

Palabras clave

Apoptosis; Influenza; Integrin; Pulmonary Fibrosis; Toll-like Receptor (TLR)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Integrinas / Factor de Crecimiento Transformador beta / Colágeno / Infecciones por Orthomyxoviridae / Células Epiteliales / Antígenos de Neoplasias Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido

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