60s-RP, 60s ribosomal protein L10E; AFABP, adipocyte fatty acid-binding protein; ALDH2, aldehyde dehydrogenase, mitochondrial; COPD, chronic obstructive pulmonary disorder; CRP1, cysteine and glycine-rich protein 1; ERK(1/2), extracellular signal regulated kinase 1/2; FACTp140, FACT complex subunit SPT16; HIP1, Huntingtin-interacting protein 1; IL, interleukin; JNK, c-Jun NH2-terminal kinase; Jak2, tyrosine-protein kinase JAK2; K18, keratin type 1 cytoskeletal 18; K8, keratin type 2 cytoskeletal 8; LIM, LIM/homeobox protein; MAPK3, mitogen-activated protein kinase 3; NF-κB, nuclear factor-kappa B; Nuclear phosphoprotein; OSF3, peroxiredoxin-1; PKC-α, protein kinase C-α; PRP19, pre-mRNA-processing factor 19; Phosphoproteomic analysis; ROS, reactive oxygen species; SPTBN1, spectrin ß chain brain 1; STAT, signal transducer and activator of transcription; Signaling pathways; TGF-ß, Transforming growth factor-ß; TIM, mitochondrial import inner membrane translocase subunit Tim9; TNF, tumor necrosis factor; TNFR2, tumor necrosis factor receptor 2; TRAP1, heat shock protein 75 kDa; Tobacco smoke exposure; p100, serine protease P100; pSTAT3-Tyr705, phosphorylated STAT3